Cerebral perfusion SPECT imaging for assessment of the effect of hyperbaric oxygen therapy on patients with postbrain injury neural status.
Shi XY, Tang ZQ, Xiong B, Bao JX, Sun D, Zhang YQ, Yao Y.
The 2nd Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310009, China. jzyx@mail.hz.zj.cn
OBJECTIVE:
To evaluate the effects of hyperbaric oxygen (HBO) therapy on
patients with postbrain injury neural status. METHODS: Two to 4 courses of
HBO therapy and/or medications were used to treat 320 patients who were
randomly divided into two groups. Assessment was made with (99m)Tc-ethyl
cysteinate dimer ( (99m)Tc-ECD) single photon emission computed tomography
(SPECT) before and after treatment.
RESULTS:
There was a significant difference between the HBO therapy group
and the non-HBO therapy group. HBO therapy was superior to medication
treatment alone in the recovery of clinical symptoms, control of epilepsy,
and resolution of hydrocephalus (P<0.01). CONCLUSIONS: HBO therapy has
specific curative effects on patients with postbrain injury neural status,
and (99m)Tc-ECD SPECT could play an important role in diagnosing postbrain
injury neural status and monitoring the therapeutic effects of HBO.
Publication Types:
* Clinical Trial
* Randomized Controlled Trial
PMID: 14642054 [PubMed - indexed for MEDLINE]
Brain Disorders/Neurological Index
